Project title: A Groundbreaking Research Project aiming to Improve Cancer Diagnosis, Treatment, and Survival in Taiwan by National Cheng Kung University Hospital Program title: Pathogenesis, biomarkers and novel regimens focusing on upper aerodigestive tract (UADT) cancers
The Interaction between Alcohol Consumption and Polymorphisms of ADH1B and ALDH2 on the Prognosis of Head and Neck Cancer
Jenn-Ren Hsiao 1, Jeffrey Shu-Ming Chang 2, Cheng-Chih Huang 1, Wei-Ting Lee 1, Sen-Tien Tsai1, Chun-Yen Ou1, Tung-Yiu Wong3, Sheen-Yie Fang1, Chan-Chi Chang1, Yu-Hsuan Lin1, Yu-Cheng Lu1, Ken-Chung Chen3, Jehn-Shyun Huang3, Jiunn-Liang Wu1, Chia-Jui Yen4, Wei-Ting Hsueh5, Yuan-Hua Wu5, Yu-Hsuan Lai5, Jang-Yang Chang2,4, Shang-Yin Wu4, Yao-Chou Lee6, Chen-Lin Lin1, Ya-Ling Weng2, Han-Chien Yan2, Yu-Shan Chen1
蕭振仁 ，張書銘，黃正池，李威霆，蔡森田，歐俊巖，王東堯，方深毅，張展旗， 林虞軒，呂宇城，陳畊仲，黃振勳，吳俊良，顏家瑞，薛尉廷，吳沅樺，賴俞璇， 張俊彥，吳尚殷，李曜洲，林貞伶，翁雅玲，楊涵茜，陳瑜珊
1Department of Otolaryngology, Medical College and Hospital, National Cheng Kung University, 2National Institute of Cancer Research, National Health Research Institutes, 3Department of Stomatology, Medical College and Hospital, National Cheng Kung University, 4Department of Internal Medicine, Medical College and Hospital, National Cheng Kung University, 5Department of Radiation Oncology, Medical College and Hospital, National Cheng Kung University, 6Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical College and Hospital, National Cheng Kung University
Background: Most studies to date have examined the influence of lifestyle factors, including alcohol drinking, on HNC risk. In contrast, less is known regarding the impact of lifestyle factors on the outcomes of HNC. Therefore, we decided to conduct an analysis to assess the role of alcohol drinking in the prognosis of HNC. Materials and Methods: The current analysis included 740 head and neck cancer (HNC) patients. Detailed information on alcohol consumption was collected by in-person interview. In addition, single nucleotide polymorphisms, rs1229984 of ADH1B and rs671of ALDH2, were genotyped. Statistical analyses were performed to evaluate the role of alcohol and the interaction between alcohol and ADH1B rs1229984 and ALDH2 rs671 on the overall survival of HNC. Results: Ever alcohol use was associated with a worse overall survival of HNC (hazard ratio (HR) = 1.43, 95% confidence interval (CI): 1.03-1.98). Furthermore, ever alcohol use was associated with a later stage and higher grade of HNC at diagnosis. The worst overall survival of HNC occurred among alcohol drinkers who carry the fast ADH1B (*2/*2) and slow/non-functional ALDH2 (*1/*2 + *2/*2) genotype combination. Conclusions: Our results suggested that alcohol use not only can increase the risk of HNC but is associated with a poorer overall survival of HNC. The HNC associated with alcohol use tended to be more aggressive with a later stage and higher grade, which may explain the worse overall survival of HNC associated with alcohol drinking.